New cancer breakthroughs


Added 11 October 2011


As October’s pink ribbons remind us, the fight against breast cancer is far from over. But after a host of recent breakthroughs, doctors are optimistic. “There’s a tremendous amount of work being done,” says Deborah Rhodes, MD, a specialist in breast cancer risk at the Mayo Clinic. “With such a multifaceted approach, we’re gradually winning the war.” Here are some of the most inspiring discoveries of 2011.   Detection The latest: A study co-authored by Rhodes found that a screening method called molecular breast imaging (MBI) is three times better than mammograms at finding small cancers in women with dense breasts (that’s at least two-thirds of women in their 40s). Patients are injected with a radioactive agent that collects in tumour cells, making them light up on a radiation-detecting camera.   The forecast: Rhodes believes MBI could be a game changer: “If we could offer an additional imaging option ideally suited to women with dense breasts, we’d have a home run.”   Progression The latest: The majority of deaths from cancer are caused not by the original tumour but by the spread of the disease. Jeffrey Pollard, PhD, of the Albert Einstein College of Medicine, has discovered that a molecule called CCL2 helps stimulate a tumour’s spread.   The forecast: Researchers could develop CCL2-inhibiting therapies that would slow metastasis or even prevent it altogether. “Over the past 20 years, there has really been no improvement in the survival of women with metastatic breast cancer,” Pollard says. “We need this type of targeted therapy to tackle the problem.”   Prognostics The latest: A May report announced that a new genetic test might be able to predict which patients with highly aggressive tumours are more likely to survive post-chemotherapy. And German researchers have identified a molecular marker that may indicate how well triple-negative cancers (the hardest kind to treat) will respond to chemotherapy.   The forecast: The ability to identify whether a patient will do better with one type of chemotherapy over another would save patients from unnecessary drugs that can cause devastating side effects or have no effect at all.   Surgery The latest: In about 40 per cent of breast cancer patients, the disease spreads to the lymph nodes in the armpit. Doctors determine whether metastasis has occurred by surgically removing a few nodes; if those nodes are cancerous, ten to 30 more may be removed—a procedure that can have debilitating side effects (including chronic swelling in the arm and chest). But a recent study found that this operation had no effect on survival rates for early-stage cases: The patients who had no further nodes removed had a prognosis as good as patients who had at least ten removed.   The forecast: With further study, Rhodes suspects the approach could become standard care for certain types of patients.   Drugs The latest: A trial conducted by the American College of Surgeons Oncology Group found that in postmenopausal women, a class of estrogen-lowering drugs called aromatase inhibitors can shrink some Stage II and III tumours enough to allow for a lumpectomy instead of mastectomy.   The forecast: The drugs could prove pivotal in reducing the national mastectomy rate of 37 per cent.   Adapted from O magazine  


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